STIM1-ulating Phagocytosis

ulating Creativity in Jazz Performance

This paper considers the problem of simulating creativity in the domain of Jazz improvisation and accompaniment. Unlike most current approaches, we try to model the musicians’ behavior by taking into account their experience and how they use it with respect to the evo)ving contexts of live performance. To represent this experience we introduce the notion of Musical Memory, which explores the pr...

STIM1 Juxtaposes ER to Phagosomes, Generating Ca2+ Hotspots that Boost Phagocytosis

BACKGROUND Endoplasmic reticulum (ER) membranes are recruited to phagosomes, but the mechanism and functional significance of this ER recruitment is not known. Here, we show that the ER Ca(2+) sensor stromal interaction molecule 1 (STIM1) sustains high-efficiency phagocytosis by recruiting thin ER cisternae that interact productively but do not fuse with phagosomes. RESULTS Endogenous STIM1 w...

UDP-Induced Phagocytosis and ATP-Stimulated Chemotactic Migration Are Impaired in STIM1−/− Microglia In Vitro and In Vivo

STIM1 is the only currently known intracellular calcium sensor that functions as the calcium influx regulator controlling immune cell activation. STIM1 function in immune cell calcium signalling has been studied extensively; however, its role in microglia, innate immune cells in brain, has not been fully understood. Here, we report that STIM1-/- murine microglia lost store-operated calcium infl...

STIM1 strengthens clotting

Cancer cells outwit the immune system long before they debut as visible tumors, say Willimsky et al. (page 1687). Despite a wealth of studies, researchers still don't know when the immune system is alerted to the presence of cancer cells or when its response is subverted. Part of the problem stems from the fact that T cell responses in most animal models are tracked only after tumors form. To g...

A stable algorithm for al ulating with some singularsplines